2024

  1. PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression.

    Xin Yang, Wei Gu.

    Journal of Molecular Cell Biology. 2024

    doi: 10.1093/jmcb/mjae033. PMID: 39210510

  2. Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs).

    Xiaoping Hu, Md Kabir, Yindan Lin, Yan Xiong, Ramon E Parsons, Wei Gu, Jian Jin.

    Journal of Medicinal Chemistry. 2024.

    doi: 10.1021/acs.jmedchem.4c01497. PMID: 39169826

  3. An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription.

    Zhenyi Su, Yanqing Liu, Zhangchuan Xia, Anil K Rustgi, Wei Gu.

    Science Advances. 2024.

    doi: 10.1126/sciadv.adm9481. PMID: 38838145

  4. PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.

    Xin Yang, Zhe Wang, Svetlana N Samovich, Alexander A Kapralov, Andrew A Amoscato, Vladimir A Tyurin, Haider H Dar, Zhiming Li, Shoufu Duan, Ning Kon, Delin Chen, Benjamin Tycko, Zhiguo Zhang, Xuejun Jiang, Hülya Bayir, Brent R Stockwell, Valerian E Kagan, Wei Gu.

    Cell Metabolism. 2024.

    doi: 10.1016/j.cmet.2024.01.006. PMID: 38309267

  5. p53 Acetylation Exerts Critical Roles in Pressure Overload–Induced Coronary Microvascular Dysfunction and Heart Failure in Mice.

    Xiaochen He, Aubrey C Cantrell, Quinesha A Williams, Wei Gu, Yingjie Chen, Jian-Xiong Chen, Heng Zeng.

    Arteriosclerosis, thrombosis, and vascular biology. 2024.

    doi: 10.1161/ATVBAHA.123.319601. PMID: 38328937

  6. GAS41 modulates ferroptosis by anchoring NRF2 on chromatin.

    Zhe Wang, Xin Yang, Delin Chen, Yanqing Liu, Zhiming Li, Shoufu Duan, Zhiguo Zhang, Xuejun Jiang, Brent R Stockwell, Wei Gu.

    Nature communications. 2024.

    doi: 10.1038/s41467-024-46857-w. PMID: 38514704

  7. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.

    Weiwei Cui, Meng Guo, Dong Liu, Peng Xiao, Chuancheng Yang, Haidi Huang, Chunhui Liang, Yinghong Yang, Xiaolong Fu, Yudan Zhang, Jiaxing Liu, Shuang Shi, Jingjing Cong, Zili Han, Yunfei Xu, Lutao Du, Chengqian Yin, Yongchun Zhang, Jinpeng Sun, Wei Gu, Renjie Chai, Shu Zhu, Bo Chu.

    Nature cell biology. 2024.

    doi: 10.1038/s41556-023-01314-6. PMID: 38168770

  8. Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death.

    Svetlana N Samovich, Karolina Mikulska‐Ruminska, Haider H Dar, Yulia Y Tyurina, Vladimir A Tyurin, Austin B Souryavong, Alexander A Kapralov, Andrew A Amoscato, Ofer Beharier, S Ananth Karumanchi, Claudette M St Croix, Xin Yang, Theodore R Holman, Andrew P VanDemark, Yoel Sadovsky, Rama K Mallampalli, Sally E Wenzel, Wei Gu, Yuri L Bunimovich, Ivet Bahar, Valerian E Kagan, Hülya Bayir.

    Angewandte Chemie International Edition. 2024.

    doi: 10.1002/anie.202314710. PMID: 38230815

  9. Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis.

    Baiyu Qiu, Fereshteh Zandkarimi, Carla T Bezjian, Eduard Reznik, Rajesh Kumar Soni, Wei Gu, Xuejun Jiang, Brent R Stockwell.

    Cell. 2024.

    doi: 10.1016/j.cell.2024.01.030. PMID: 38366593

2023

  1. Protocol of CRISPR-Cas9 knockout screens for identifying ferroptosis regulators.

    Xin Yang, Shoufu Duan, Zhiming Li, Zhe Wang, Ning Kon, Zhiguo Zhang, Wei Gu.

    STAR protocols. 2023.

    doi: 10.1016/j.xpro.2023.102762. PMID: 38048220

  2. Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring.

    William W Feng, Scott Bang, Eric M Takacs, Cora Day, Katherine J Crawford, Ruba Al-Sheyab, Dara B Almufarrej, Wendy Wells, Serguei Ilchenko, Takhar Kasumov, Ning Kon, Colleen M Novak, Wei Gu, Manabu Kurokawa.

    Iscience. 2023.

    doi: 10.1016/j.isci.2023.108405. PMID: 38047073

  3. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.

    Ling Zhang, Jun Zhang, Xiaofeng Xuan, Di Wu, Jianfeng Yu, Peizhen Wang, Xiaomei Yang, Jieru Zhang, Wenjuan Gan, Mengfan He, Xiao-Min Liu, Jun Zhou, Donglai Wang, Wei Gu, Dawei Li.

    Cell Rep. 2023.

    doi: 10.1016/j.celrep.2023.112833. PMID: 37480565

  4. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.

    Xin Yang, Zhe Wang, Fereshteh Zandkarimi, Yanqing Liu, Shoufu Duan, Zhiming Li, Ning Kon, Zhiguo Zhang, Xuejun Jiang, Brent R Stockwell, Wei Gu.

    Cell Metab. 2023.

    doi: 10.1016/j.cmet.2023.06.014. PMID: 37467745

  5. Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.

    Md Kabir, Ning Sun, Xiaoping Hu, Tiphaine C Martin, Jingjie Yi, Yue Zhong, Yan Xiong, H Ümit Kaniskan, Wei Gu, Ramon Parsons, Jian Jin.

    J Am Chem Soc. 2023.

    doi: 10.1021/jacs.3c04640. PMID: 37365684

  6. Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1.

    Jingjie Yi, Huan Li, Bo Chu, Ning Kon, Xiaoping Hu, Jianping Hu, Yan Xiong, H Umit Kaniskan, Jian Jin, Wei Gu.

    Cell Death Differ. 2023.

    doi: 10.1038/s41418-023-01180-7. PMID: 37291217

  7. Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones.

    Deguang Liang, Yan Feng, Fereshteh Zandkarimi, Hua Wang, Zeda Zhang, Jinnie Kim, Yanyan Cai, Wei Gu, Brent R Stockwell, Xuejun Jiang.

    Cell. 2023.

    doi: 10.1016/j.cell.2023.05.003. PMID: 37267948

  8. SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation.

    Han Su, Aubrey C Cantrell, Jian-Xiong Chen, Wei Gu, Heng Zeng.

    Cells. 2023.

    doi: 10.3390/cells12101428. PMID: 37408261

  9. Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.

    Jingjie Yi, Omid Tavana, Huan Li, Donglai Wang, Richard J Baer, Wei Gu.

    Nature Communications. 2023.

    doi: 10.1038/s41467-023-37617-3. PMID: 37024504

  10. Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism.

    Zhenyi Su, Ning Kon, Jingjie Yi, Haiqing Zhao, Wanwei Zhang, Qiaosi Tang, Huan Li, Hiroki Kobayashi, Zhiming Li, Shoufu Duan, Yanqing Liu, Kenneth P Olive, Zhiguo Zhang, Barry Honig, James J Manfredi, Anil K Rustgi, Wei Gu.

    Nature Cancer. 2023

    doi: 10.1038/s43018-023-00532-z. PMID: 36973430

  11. ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease.

    Shujuan Song, Zhenyi Su, Ning Kon, Bo Chu, Huan Li, Xuejun Jiang, Jianyuan Luo, Brent R Stockwell, Wei Gu.

    Genes Dev. 2023.

    doi: 10.1101/gad.350211.122. PMID: 36921996

  12. Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth.

    Dong Liu, Chun-hui Liang, Bin Huang, Xiao Zhuang, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin, Renjie Chai, Bo Chu.

    Adv Sci (Weinh). 2023.

    doi: 10.1002/advs.202204006. PMID: 36627132

2022

  1. Epigenome programming by H3. 3K27M mutation creates a dependence of pediatric glioma on SMARCA4.

    Yan Mo, Shoufu Duan, Xu Zhang, Xu Hua, Hui Zhou, Hong-Jian Wei, Jun Watanabe, Nicholas McQuillan, Zhenyi Su, Wei Gu, Cheng-Chia Wu, Christopher R Vakoc, Rintaro Hashizume, Kenneth Chang, Zhiguo Zhang.

    Cancer Discov. 2022.

    doi: 10.1158/2159-8290.CD-21-1492. PMID: 36305747

  2. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation.

    Zhang P, Gao K, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C.

    Cell Death Differ. 2022.

    doi: 10.1038/s41418-021-00890-0. PMID: 34743205

  3. CNPY2 Contributes to Liver Oncogenesis by Promoting UPR-dependent destabilization of p53.

    Hong F, Lin CY, Yan J, Dong Y, Ouyang Y, Kim D, Zhang X, Liu B, Sun S, Gu W, Li Z.

    Hepatology. 2022.

    doi: 10.1002/hep.32318. PMID: 34986508

2021

  1. An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation

    Yang X, Wang X, Li Z, Duan S, Li H, Jin J, Zhang Z, Gu W.

    Sci Adv. 2021.

    doi: 10.1126/sciadv.abi6684. PMID: 34705508

  2. The roads to ferroptosis under homeostatic versus pathological conditions

    Vincent Chen, Chu Bo, Wei Gu

    Molecular & Cellular Oncology. 2021.

    doi.org/10.1080/23723556.2021.1970477. PMID: 34859139

  3. Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis.

    Cui W, Liu D, Gu W, Chu B.

    Cell Death Differ. 2021.

    doi: 10.1038/s41418-021-00769-0. PMID: 33731874

  4. iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.

    Chen D, Chu B, Yang X, Liu Z, Jin Y, Kon N, Rabadan R, Jiang X, Stockwell BR, Gu W.

    Nat Commun. 2021.

    doi: 10.1038/s41467-021-23902-6. PMID: 34131139

  5. p53 activation vs. stabilization: an acetylation tale from the C-terminal tail.

    Kon N, Gu W.

    Oncoscience. 2021.

    doi: 10.18632/oncoscience.534. PMID: 33997110

  6. An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation.

    Cao Z, Kon N, Liu Y, Xu W, Wen J, Yao H, Zhang M, Wu Z, Yan X, Zhu WG, Gu W, Wang D.

    Sci Adv. 2021.

    doi: 10.1126/sciadv.abf4148. PMID: 33789902

  7. Mutant p53 regulates Survivin to foster lung metastasis.

    Tang Q, Efe G, Chiarella AM, Leung J, Chen M, Yamazoe T, Su Z, Pitarresi JR, Li J, Islam M, Karakasheva T, Klein-Szanto AJ, Pan S, Hu J, Natsugoe S, Gu W, Stanger BZ, Wong KK, Diehl JA, Bass AJ, Nakagawa H, Murphy ME, Rustgi AK.

    Genes Dev. 2021.

    doi: 10.1101/gad.340505.120. PMID: 33737385

  8. Sirt1 coordinates with ERα to regulate autophagy and adiposity.

    Tao Z, Shi L, Parke J, Zheng L, Gu W, Dong XC, Liu D, Wang Z, Olumi AF, Cheng Z.

    Cell Death Discov. 2021.

    doi: 10.1038/s41420-021-00438-8. PMID: 33723227

  9. Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).

    Shaw TI, Dong L, Tian L, Qian C, Liu Y, Ju B, High A, Kavdia K, Pagala VR, Shaner B, Pei D, Easton J, Janke LJ, Porter SN, Ma X, Cheng C, Pruett-Miller SM, Choi J, Yu J, Peng J, Gu W, Look AT, Downing JR, Zhang J.

    Sci Rep. 2021.

    doi: 10.1038/s41598-021-84647-2. PMID: 33664368

  10. The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.

    Meng C, Zhan J, Chen D, Shao G, Zhang H, Gu W, Luo J.

    Oncogene. 2021.

    doi: 10.1038/s41388-021-01660-5. PMID: 33531626

  11. Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress.

    Jin Y, Gu W, Chen W.

    J Mol Cell Biol. 2021.

    doi: 10.1093/jmcb/mjaa074. PMID: 33377976

  12. Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function.

    Kon N, Churchill M, Li H, Mukherjee S, Manfredi JJ, Gu W.

    Cancer Res. 2021.

    doi: 10.1158/0008-5472.CAN-20-1804. PMID: 33323382

  13. mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

    Kon N, Ou Y, Wang SJ, Li H, Rustgi AK, Gu W.

    Genes Dev. 2021.

    doi: 10.1101/gad.340919.120. PMID: 33303641

  14. Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.

    Pluciennik A, Liu Y, Molotsky E, Marsh GB, Ranxhi B, Arnold FJ, St-Cyr S, Davidson B, Pourshafie N, Lieberman AP, Gu W, Todi SV, Merry DE.

    J Clin Invest. 2021.

    doi: 10.1172/JCI134565. PMID: 33170804