2020

1. X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.

   Eisa AA, Bang S, Crawford KJ, Murphy EM, Feng WW, Dey S, Wells W, Kon N, Gu W, Mehlmann LM, Vijayaraghavan S, Kurokawa M.

   iScience. 2020

   doi: 10.1016/j.isci.2020.101523. PMID: 32927266

2. OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.

   Li F, Sun Q, Liu K, Zhang L, Lin N, You K, Liu M, Kon N, Tian F, Mao Z, Li T, Tong T, Qin J, Gu W, Li D, Zhao W.

   Nat Commun. 2020

   doi: 10.1038/s41467-020-17926-7. PMID: 32826889

3. SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle.

   Lu YF, Xu XP, Lu XP, Zhu Q, Liu G, Bao YT, Wen H, Li YL, Gu W, Zhu WG.

   Oncogene. 2020

   doi: 10.1038/s41388-020-1305-5. PMID: 32404984

4. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.

   Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH.

   Nat Commun. 2020

   doi: 10.1038/s41467-020-16038-6. PMID: 32385263

5. Cysteine depletion induces pancreatic tumor ferroptosis in mice.

   Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP.

   Science. 2020.

   doi: 10.1126/science.aaw9872. PMID: 32241947

2019

1. Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A.

   Wang Z, Yang X, Liu C, Li X, Zhang B, Wang B, Zhang Y, Song C, Zhang T, Liu M, Liu B, Ren M, Jiang H, Zou J, Liu X, Zhang H, Zhu WG, Yin Y, Zhang Z, Gu W, Luo J.

   Mol Cell. 2019.

   doi: 10.1016/j.molcel.2019.04.009. PMID: 31054974

2. Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix.

   He L, Zhou J, Chen M, Lin CS, Kim SG, Zhou Y, Xiang L, Xie M, Bai H, Yao H, Shi C, Coelho PG, Bromage TG, Hu B, Tovar N, Witek L, Wu J, Chen K, Gu W, Zheng J, Sheu TJ, Zhong J, Wen J, Niu Y, Cheng B, Gong Q, Owens DM, Stanislauskas M, Pei J, Chotkowski G, Wang S, Yang G, Zegarelli DJ, Shi X, Finkel M, Zhang W, Li J, Cheng J, Tarnow DP, Zhou X, Wang Z, Jiang X, Romanov A, Rowe DW, Wang S, Ye L, Ling J, Mao J.

   Nat Mater. 2019.

   doi: 10.1038/s41563-019-0368-6. PMID: 31114073

3. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.

   Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W.

   Nature. 2019.

   doi: 10.1038/s41586-019-1170-y. PMID: 31043744

4. ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.

   Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W.

   Nat Cell Biol. 2019.

   doi: 10.1038/s41556-019-0305-6. PMID: 30962574

5. p53 β-hydroxybutyrylation attenuates p53 activity.

   Liu K, Li F, Sun Q, Lin N, Han H, You K, Tian F, Mao Z, Li T, Tong T, Geng M, Zhao Y, Gu W, Zhao W.

   Cell Death Dis. 2019.

   doi: 10.1038/s41419-019-1463-y. PMID: 30858356

6. Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.

   Kon N, Wang D, Gu W.

   Cell Death Dis. 2019.

   doi: 10.1038/s41419-019-1484-6. PMID: 30858352

7. The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11.

   Liu T, Jiang L, Tavana O, Gu W.

   Cancer Res. 2019.

   doi: 10.1158/0008-5472.CAN-18-3037. PMID: 30709928

8. Ferroptosis as a target for protection against cardiomyopathy.

   Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F.

   Proc Natl Acad Sci U S A. 2019.

   doi: 10.1073/pnas.1821022116. PMID: 30692261

9. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner.

   Liu B, Yi J, Yang X, Liu L, Lou X, Zhang Z, Qi H, Wang Z, Zou J, Zhu WG, Gu W, Luo J.

   Oncogene. 2019.

   doi: 10.1038/s41388-018-0605-5. PMID: 30532073

10. Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry.

    Sowers ML, Herring J, Zhang W, Tang H, Ou Y, Gu W, Zhang K.

    Anal Biochem. 2019.

    doi: 10.1016/j.ab.2018.10.026. PMID: 30409761

2018

1. p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis.

   Li M, Hou T, Gao T, Lu X, Yang Q, Zhu Q, Li Z, Liu C, Mu G, Liu G, Bao Y, Wen H, Wang L, Wang H, Zhao Y, Gu W, Yang Y, Zhu WG.

   Cell Death Dis. 2018.

   doi: 10.1038/s41419-018-0984-0.PMID: 30237540

2. Is MDMX the better target?

   Kon N, Gu W.

   Aging (Albany NY). 2018.

   doi: 10.18632/aging.101479.PMID: 29905531

3. Peli1 Modulates the Subcellular Localization and Activity of Mdmx.

   Li D, Tavana O, Sun SC, Gu W.

   Cancer Res. 2018.

   doi: 10.1158/0008-5472.CAN-17-3531. PMID: 29523541

4. Independent functions of DNMT1 and USP7 at replication foci.

   Yarychkivska O, Tavana O, Gu W, Bestor TH.

   Epigenetics Chromatin. 2018.

   doi: 10.1186/s13072-018-0179-z.PMID: 29482658

5. Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects.

   Kon N, Wang D, Li T, Jiang L, Qiang L, Gu W.

   Oncotarget. 2018.

   doi: 10.18632/oncotarget.23837. PMID: 29484110

6. ARF-NRF2: A new checkpoint for oxidative stress responses?

   Chen D, Tavana O, Gu W.

   Mol Cell Oncol . 2018.

   doi: 10.1080/23723556.2018.1432256.PMID: 30250887

7. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

   Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y.

   Cell Res. 2018.

   doi: 10.1038/cr.2017.149.PMID: 29192674

8. SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.

   Yang X, Wang Z, Li X, Liu B, Liu M, Liu L, Chen S, Ren M, Wang Y, Yu M, Wang B, Zou J, Zhu WG, Yin Y, Gu W, Luo J.

   Cancer Res. 2018.

   doi: 10.1158/0008-5472.CAN-17-1912. PMID: 29180469

2017

1. NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression.

   Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, Gu W.

   Mol Cell. 2017.

   doi: 10.1016/j.molcel.2017.09.009.PMID: 28985506

2. The "readers" of unacetylated p53 represent a new class of acidic domain proteins.

   Wang D, Kon N, Tavana O, Gu W.

   Nucleus. 2017.

   doi: 10.1080/19491034.2017.1313939.PMID: 28406743

3. Modulation of the p53/MDM2 interplay by HAUSP inhibitors.

   Tavana O, Gu W.

   J Mol Cell Biol. 2017.

   doi: 10.1093/jmcb/mjw049.PMID: 27927749

4. Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors.

   Chen C, Song J, Wang J, Xu C, Chen C, Gu W, Sun H, Wen X.

   Bioorg Med Chem Lett. 2017.

   doi: 10.1016/j.bmcl.2017.01.018. PMID: 28108249

2016

1. Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.

   Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW.

   EBioMedicine. 2016.

   doi: 10.1016/j.ebiom.2016.10.018. PMID: 27769803

2. Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression.

   Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao Y, Gu W.

   Cell Rep. 2016.

   doi: 10.1016/j.celrep. PMID: 27705786

3. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.

   Ou Y, Wang SJ, Li D, Chu B, Gu W.

   Proc Natl Acad Sci USA. 2016.

   doi: 10.1073/pnas.1607152113. PMID: 27698118

4. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.

   Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W.

   Nature. 2016.

   doi: 10.1038/nature19759. PMID: 27626385

5. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma.

   Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W.

   Nat Med. 2016.

   doi: 10.1038/nm.4180. PMID: 27618649

6. Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.

   Wang Y, Zhang N, Zhang L, Li R, Fu W, Ma K, Li X, Wang L, Wang J, Zhang H, Gu W, Zhu WG, Zhao Y.

   Mol Cell. 2016.

   doi: 10.1016/j.molcel.2016.05.027. PMID: 27345151

7. FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease.

   Schneider C, Kon N, Amadori L, Shen Q, Schwartz FH, Tischler B, Bossennec M, Dominguez-Sola D, Bhagat G, Gu W, Basso K, Dalla-Favera R.

   Blood. 2016.

   doi: 10.1182/blood-2015-11-684357. PMID: 27166359

8. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging.

   Li T, Liu X, Jiang L, Manfredi J, Zha S, Gu W.

   Oncotarget. 2016.

   doi: 10.18632/oncotarget.7864. PMID: 26943586

9. Parkin Regulates the Activity of Pyruvate Kinase M2.

   Liu K, Li F, Han H, Chen Y, Mao Z, Luo J, Zhao Y, Zheng B, Gu W, Zhao W.

   J Biol Chem. 2016.

   doi: 10.1074/jbc.M115.703066. PMID: 26975375

10. Ferroptosis: A missing puzzle piece in the p53 blueprint?

    Wang SJ, Ou Y, Jiang L, Gu W.

    Mol Cell Oncol. 2015.

    doi: 10.1080/23723556.2015.1046581.PMID: 27314071

11. USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation.

    Mungamuri SK, Qiao RF, Yao S, Manfredi JJ, Gu W, Aaronson SA.

    Cell Rep. 2016.

    doi: 10.1016/j.celrep.2016.02.049. PMID: 26971997

12. USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168.

    Yu M, Liu K, Mao Z, Luo J, Gu W, Zhao W.

    J Biol Chem. 2016.

    doi: 10.1074/jbc.M114.624478. PMID: 26507658

13. Negative regulation of the p300-p53 interplay by DDX24.

    Shi D, Dai C, Qin J, Gu W.

    Oncogene. 2016.

    doi: 10.1038/onc.2015.77. PMID: 25867071